Expression of verotoxin-1 receptor Gb3 in breast cancer tissue and verotoxin-1 signal transduction to apoptosis
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منابع مشابه
Verotoxin-1 Treatment or Manipulation of its Receptor Globotriaosylceramide (Gb3) for Reversal of Multidrug Resistance to Cancer Chemotherapy
A major problem with anti-cancer drug treatment is the development of acquired multidrug resistance (MDR) of the tumor cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the globotriaosylceramide membrane receptor (Gb3), a glycolipid associated with multidrug resistance. Gb3 is overexpressed in many human tumors and tumor cell lines with inherent or acquired MDR. Gb3 is co-expressed...
متن کاملNMR studies on the dynamics and structure of Verotoxin-1 B subunits binding to its functional plasma membrane receptor, Globotriaosylceramide, Gb3
Introduction Verotoxin (VT) was first reported by Konowalchuk et al. in 1977. Although VT-producing E. coli strains belong to several different serotypes, 0157:H7 is the dominant serotype isolated from patients suffering from food poisoning. The infection frequently develops into hemorrhagic colitis. Furthermore, about 10% of these cases develop into the haemolytic uremic syndrome, which is the...
متن کاملToxicity and immunogenicity of a verotoxin 1 mutant with reduced globotriaosylceramide receptor binding in rabbits.
The verotoxins (VT1 and VT2), produced by strains of enterohemorrhagic Escherichia coli, have been implicated in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome. To better understand the role of globotriaosylceramide (Gb3) receptor binding by the verotoxins in disease production, we examined the clinicopathologic effects of an intravenously (i.v.) administered verotoxi...
متن کاملHaemorrhagic colitis: detection of verotoxin
Faeces (n = 1319) were examined over three months for the presence of non-sorbitol fermenting, verotoxin producing Escherichia coli (serotype 0157). Seven isolates were found, four from patients with bloodstained diarrhoea and three from patients with no evidence of blood in the faeces. Screening of all faecal samples with specific 0157 antiserum for non-sorbitol fermenting organisms and agglut...
متن کاملHigh Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer
Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 i...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2009
ISSN: 1471-2407
DOI: 10.1186/1471-2407-9-67